Protein Domain : Novel protein kinase C delta, catalytic domain IPR034667

Type	Domain
Description	Protein kinases C (PKCs) constitute a family of Ser/Thr kinases. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain [ , ]. Novel PKCs (nPKCs) comprise delta, epsilon, eta, and theta isoforms, which have tandem C1 domains and a C2 domain that does not bind calcium []. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. PKC-delta plays a role in cell cycle regulation and programmed cell death in many cell types [ , , ]. It slows down cell proliferation, inducing cell cycle arrest and enhancing cell differentiation. PKC-delta is also involved in the regulation of transcription as well as immune and inflammatory responses [, ]. It plays a central role in the genotoxic stress response that leads to DNA damaged-induced apoptosis [].
Short Name	nPKC_delta