Protein Domain : Atypical Protein Kinase C zeta, catalytic domain IPR034662

Type	Domain
Description	PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their N-terminal regulatory domain [ , ]. Atypical protein kinases C (aPKCs) have a PB1 and an atypical C1 domain, which only accepts phosphatidylserine [].In mammals there are two aPKC isoforms, zeta and iota/lambda (iota is the human orthologue and lambda the mouse orthologue) [ ]. aPKCs are involved in many cellular functions including proliferation, migration, apoptosis, polarity maintenance and cytoskeletal regulation [, ]. They also play a critical role in the regulation of glucose metabolism and in the pathogenesis of type 2 diabetes [, ].PKC-zeta plays a critical role in activating the glucose transport response [ , ]. PKC-zeta also plays a central role in maintaining cell polarity in yeast and mammalian cells []. In addition, it affects actin remodeling in muscle cells [].
Short Name	aPKC_zeta