v5.1.0.3
Cicer data from the Legume Information System
| Type | Domain |
| Description | Intracellular chloride ion channel proteins (CLICs) has been shown to exist in both soluble and integral membrane forms. Chloride intracellular channel protein 1 (CLIC1) can insert into membranes and form chloride ion channels [ ]. Membrane insertion seems to be redox-regulated and may occur only under oxydising conditions []. Channel activity has been shown to have a strong pH dependence []. The soluble form of CLIC1 is monomeric and structurally homologous to the glutathione S-transferase superfamily, with a redox-active site resembling glutaredoxin [].CLIC1 (also known as NCC27) is involved in regulation of the cell cycle [ ].This entry represents the C-terminal, alpha helical domain of CLIC1 [ ]. |
| Short Name | CLIC-1_C |