Protein Domain : Chloride intracellular channel protein 1, C-terminal domain IPR030259

Type  Domain
Description  Intracellular chloride ion channel proteins (CLICs) has been shown to exist in both soluble and integral membrane forms. Chloride intracellular channel protein 1 (CLIC1) can insert into membranes and form chloride ion channels [ ]. Membrane insertion seems to be redox-regulated and may occur only under oxydising conditions []. Channel activity has been shown to have a strong pH dependence []. The soluble form of CLIC1 is monomeric and structurally homologous to the glutathione S-transferase superfamily, with a redox-active site resembling glutaredoxin [].CLIC1 (also known as NCC27) is involved in regulation of the cell cycle [ ].This entry represents the C-terminal, alpha helical domain of CLIC1 [ ].
Short Name  CLIC-1_C

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