Protein Domain : GREB1, N-terminal domain IPR046926

Type	Domain
Description	GREB1 (gene regulated in breast cancer 1 protein) is a ESR1 (estrogen receptor 1)-upregulated protein that may regulate estrogen action and it is associated with estrogen-stimulated cell proliferation [ ]. It acts as a regulator of hormone-dependent cancer growth in breast, ovarian and prostate cancers [, , , ]. This protein may be a target to inhibit tumour-promoting pathways both downstream and independent of ESR1 as a possible treatment strategy.This entry represents a the N-terminal domain of GREB1 and similar proteins, whose function is not yet known. Structure predictions suggest that it may have an α/β fold.
Short Name	GREB1_N