Protein Domain : Arginine vasopressin-induced protein 1/transcriptional and immune response regulator IPR020282

Type  Domain
Description  This entry includes arginine vasopressin-induced protein 1 (Avpi1) and C8orf4 protein. Avpi1 is thought to be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling [ ]. C8orf4, also known as transcriptional and immune response regulator (TCIM) or thyroid cancer 1 (TC-1), plays important roles in many signalling pathways, such as Wnt/beta-catenin signalling pathway, and is involved in the development of many cancers []. C8orf4 also suppresses NOTCH2 signalling in liver cancer stem cells [ ].
Short Name  Avpi1/C8orf4_dom
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