Protein Domain : Cyclin-dependent kinase inhibitor, plant IPR044275

Type	Family
Description	This entry represents a group of plant cyclin-dependent kinase inhibitors (CKIs), including KRP1-7 (Kip-related proteins 1-7) from Arabidopsis [ ]. Plant CKIs fall into 2 distinct families, KIP-RELATED PROTEINS (KRPs) and SIAMESE-RELATED proteins (SMRs). KRPs share very little sequence similarity with mammalian KIP proteins outside the C-terminal conserved region. Compare to mammalian CKIs, plant KRP1-KRP7 bind to active cyclin D2 (CYCD2)/CDKA and CYCD2/CDKB complexes to a similar extent, however, they inhibit kinase activity to a different extent [ ]. KRPs function as a dose-dependent cell cycle inhibitors and have an important function in cell proliferation as well as in cell cycle exit and in turning from a mitotic to an endoreplicating cell cycle mode [].
Short Name	KRP