Protein Domain : BRAP2, RNA recognition motif IPR034932

Type	Domain
Description	This entry represents the RNA recognition motif (RRM) of BRAP2, also known as BRCA1-associated protein, a novel cytoplasmic protein interacting with the two functional nuclear localisation signal (NLS) motifs of BRCA1, a nuclear protein linked to breast cancer. It also binds to the SV40 large T antigen NLS motif and the bipartite NLS motif found in mitosin [ ]. BRAP2 may serve as a cytoplasmic retention protein and play a role in the regulation of nuclear protein transport [, ]. It has been shown to act as a negative regulator of nuclear import of viral proteins []. It contains an N-terminal RNA recognition motif (RRM), followed by a C3HC4-type ring finger domain and a UBP-type zinc finger.
Short Name	BRAP2_RRM