Protein Domain : Involucrin, N-terminal IPR019571

Type	Domain
Description	Involucrin [ , ] is a highly reactive, soluble, transglutaminase substrate protein present in keratinocytes of epidermis and other stratified squamous epithelia. Involucrin first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase thus helping in the formation of an insoluble envelope beneath the plasma membrane [] functioning as a glutamyldonor during assembly of the cornified envelope. Structurally involucrin consists of a conserved region of about 75 amino acid residues followed by two extremely variable length segments that containglutamine-rich tandem repeats. The glutamine residues in the tandem repeats are the substrate for the tranglutaminase in the cross-linking reaction. Thetotal size of the protein varies from 285 residues (in dog) to 835 residues (in orangutan).This is the N-terminal three beta strands of involucrin, a protein present in keratinocytes of epidermis and other stratified squamous epithelia. Apigenin is a plant-derived flavanoid that has significant promise as a skin cancer chemopreventive agent. It has been found that apigenin regulates normal human keratinocyte differentiation by suppressing it and this is associated with reduced cell proliferation without apoptosis [ ]. The downstream part of the protein is represented by .
Short Name	Involucrin_N