Protein Domain : Sorting nexin-33, BAR domain IPR037427

Type	Domain
Description	Sorting nexins are a large family of evolutionarily conserved phosphoinositide-binding proteins that have roles in cargo sorting through the endosomal netwrok [ ]. Sorting nexins contain at least a PX domain (a phospholipid-binding motif). Some nexins contain a few additional domains. Proteins in the sorting nexin 9 subfamily includes SNX9, SNX18 and SNX33 [ ]. They are characterised by the presence of an N-terminal SH3 domain (), a PX domain that is a phosphoinositide-binding module ( ), and a Bin/Amphiphysin/Rvs (BAR) domain at the C terminus, which allows membrane binding and bending. They are required for progression and completion of mitosis [ ]. SNX33 plays a role in maintaining cell shape and cell cycle progression through its interaction with WASp (Wiskott-Aldrich syndrome protein) [ ]. It interferes with cellular prion protein (PrP) formation by modulation of its shedding []. It may also promote the formation of macropinosomes (large endocytic organelles) []. This entry represents the BAR domain of SNX33. BAR domains are dimerization, lipid binding and curvature sensing modules found in many different proteins with diverse functions [ ].
Short Name	SNX33_BAR