Protein Domain : Protein phosphatase 1, regulatory subunit 15B, N-terminal IPR019512

Type  Domain
Description  This entry represents the conserved N-terminal domain of the regulatory subunit (15B) of protein phosphatase 1 (also known as CReP, or the constitutive repressor of eIF2alpha phosphorylation). The CReP catalytic subunit functions in the dephosphorylation of eIF2-alpha under basal conditions in the absence of stress. In response to translation inhibition, there is reduced synthesis of the labile CReP that contributes to elevated levels of eIF2-alpha phosphorylation []. The C terminus, family PP1c, is shared with the apoptosis-associated protein Gadd34 and herpes simplex virus [].
Short Name  Prot_Pase1_reg-su15B_N

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