Protein Domain : F-BAR domain only protein 2, F-BAR domain IPR030122

Type	Domain
Description	F-BAR domain only protein 2 (FCHo2) belongs to the F-BAR family, whose members have been implicated in cell membrane processes such as membrane invagination, tubulation and endocytosis [ ]. FCHo2 organises clathrin-coated structures and interacts with adaptor Disabled-2 for low-density lipoprotein receptor endocytosis [ , ]. The structure of the FCHo2 F-BAR domain has been solved [].This entry represents the N-terminal F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCHo2. This domain form banana-shaped dimers with a positively-charged concave surface that binds to negatively-charged lipid membranes. These dimers can induce membrane deformation in the form of long tubules [ ].
Short Name	FCHo2_F-BAR