Protein Domain : TRP-interacting helix, InaF motif IPR029162

Type	Conserved_site
Description	This highly conserved motif is thought to be a transmembrane helix that binds to transient receptor potential (TRP) calcium channel. It is found in proline-rich protein 24 (PRR24) and in InaF proteins. It is known that proline-rich proteins inactivate tannins found in food compounds, and it is thought that PRR24 does too. This is important since tannins often inhibit the uptake of iron [ ]. InaF is a protein required for TRP calcium channel function in Drosophila [, ]. TRP-related channels have been suggested to mediate "store-operated"calcium entry, important for Ca2+ homeostasis in a wide variety of cell types [ ].
Short Name	InaF-motif