Protein Domain : HEPN domain IPR007842

Type	Domain
Description	The HEPN (higher eukaryotes and prokaryotes nucleotide-binding) domain is a region of 110 residues found in the C terminus of sacsin, a chaperonin implicated in an early-onset neurodegenerative disease in human, and in manybacterial and archeabacterial proteins. There are three classes of proteins with HEPN domain:Single-domain HEPN proteins found in many bacteria.Two-domain proteins with N-terminal nucleotidyltransferase (NT) and C- terminal HEPN domains. This N-terminal NT domain belongs to a large familyof NTs, which includes several classes of enzymes that are responsible for some types of bacterial resistance to aminoglycosides. These enzymesdeactivate various antibiotics by transferring a nucleotidyl group to the drug.A multidomain sacsin protein in genomes of fish and mammals. The HEPN domain is located at the C terminus of the protein, directly after the DnaJdomain ( ). The crystal structure of the HEPN domain from the TM0613 protein of Thermotoga maritima indicates that it is structurally similar to the C-terminal all- α-helical domain of kanamycin nucleotidyltransferases (KNTases). It is composed of five alpha helices, three of which form an up-and-down helical bundle, with a pair of short helices on the side. The distant structural similarity suggests that the HEPN domain might be involved innucleotide binding [ ].
Short Name	HEPN_dom