Protein Domain : Coenzyme A biosynthesis bifunctional protein CoaBC IPR005252

Type	Family
Description	This entry represents a bifunctional enzyme CoaBC (gene name dfp) that catalyses the second and third steps (cysteine ligation, ( ), and decarboxylation, ( )) in the biosynthesis of coenzyme A (CoA) from pantothenate in bacteria. This enzyme contains the FMN cofactor, but no FAD or pyruvoyl group. The amino-terminal region is responsible for the phosphopantothenoylcysteine decarboxylase activity [ ].The protein product of the dfp gene in Escherichia coli was found to be able to restore a temperature-sensitive conditionally lethal mutation that resulted in a slow cessation of DNA synthesis [ ]. The protein encoded by dfp was then found to affect both DNA and pantothenate metabolism []. Later, phosphopantothenate-cysteine ligase activity, which is involved in the biosynthesis of coenzyme A, was demonstrated in the same protein. Therefore this protein has been named bifunctional protein CoaBC [].
Short Name	CoaBC