Protein Domain : Alkylated DNA repair protein alkB homologue 3 IPR032854

Type  Family
Description  AlkB proteins are dioxygenases that repair alkylation damage to DNA and RNA [ ]. Nine mammalian AlkB homologues exist (ALKBH1-8, FTO), but only a subset functions as DNA/RNA repair enzymes [].This entry represents AlkB homologue 3 (ALKBH3, ABH3), which has a strong preference for single-stranded DNA also demethylates 1-methyladenine (1meA) and 3-methylcytosine (3meC) in RNA [ , , ]. ALKBH3 is overexpressed in various cancers and contributes to cancer cell survival [, , ].
Short Name  ALKBH3

0 Child Features

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4 Ontology Annotations

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