Protein Domain : AT-rich interactive domain-containing protein 5B, ARID/BRIGHT DNA binding domain IPR030408

Type  Domain
Description  ARID5B, also known as modulator recognition factor-2 (Mrf-2), is a member of the AT-rich interaction domain (ARID) family of transcription factors [ ]. Human ARID5B forms complex with PHF2, a jmjC demethylase; this complex serves as a signal-sensing modulator of histone methylation and gene transcription []. It facilitates chondrogenesis by recruiting the histone demethylase PHF2 to Sox9-regulated genes []. Mouse Mrf-2 is required for adipogenesis and to maintain normal functions in mature adipocytes []. The genetic variations in the ARID5B gene have been linked to susceptibility to type 2 diabetes [ ], acute lymphoblastic leukemia [] and coronary atherosclerosis []. This entry represents the AT-rich ARID/BRIGHT DNA binding domain of ARID5B.
Short Name  ARID5B_ARID/BRIGHT_DNA-bd
Paste the following link
Lists
This ProteinDomain isn't in any lists. Upload a list.

0 Child Features

0 Gene Families

0 Genes

0 Ontology Annotations

1 Parent Features

Trail: ProteinDomain

0 Publications

USDA
InterMine logo
The Legume Information System (LIS) is a research project of the USDA-ARS:Corn Insects and Crop Genetics Research in Ames, IA.
LegumeMine || ArachisMine | CicerMine | GlycineMine | LensMine | LupinusMine | PhaseolusMine | VignaMine | MedicagoMine
InterMine © 2002 - 2022 Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, United Kingdom