LIS - Legume Information System
Information about legume traits for crop improvement
CicerMine
v5.1.0.3
Cicer data from the Legume Information System
v5.1.0.3
Cicer data from the Legume Information System
| Type | Family |
| Description | Protrudin is a membrane protein that regulates polarized vesicular trafficking in neurons. It interacts with KIF5, a motor protein that mediates anterograde vesicular transport in neurons [ ]. Protrudin contains a Rab11-binding domain, a FYVE (lipid-binding) domain, and a short sequence motif designated FFAT (two phenylalanines in an acidic tract) between the Rab11 binding domain and the FYVE domain. The FFAT motif mediates the interaction of protrudin with vesicle-associated membrane protein-associated protein (VAP) as well as with Kif5A. Protrudin has been linked to Hereditary spastic paraplegia (HSP), an inherited neurological disorders characterised by progressive lower-limb spasticity and weakness. []. |
| Short Name | Protrudin |
