LIS - Legume Information System
Information about legume traits for crop improvement
CicerMine
v5.1.0.3
Cicer data from the Legume Information System
v5.1.0.3
Cicer data from the Legume Information System
| Type | Domain |
| Description | The ABC transporter family is a group of membrane proteins that use the hydrolysis of ATP to power the translocation of a wide variety of substrates across cellular membranes. ABC transporters minimally consist of two conserved regions: a highly conserved nucleotide-binding domain (NBD) and a less conserved transmembrane domain (TMD). Eukaryotic ABC proteins are usually organised either as full transporters (containing two NBDs and two TMDs), or as half transporters (containing one NBD and one TMD), that have to form homo- or heterodimers in order to constitute a functional protein [ ].This group of proteins includes ATP-binding cassette sub-family C member 4 (ABCC4, also known as Multidrug resistance-associated protein 4, MRP4) from animals. It belongs to the MRP (multidrug resistance protein) subfamily of the ATP-binding cassette (ABC) transporter family [ ]. MRP4 is a broad specificity organic anion exporter that seems to be able to mediate the transport of conjugated steroids, prostaglandins, and glutathione []. It can localise to both basolateral and apical membranes in polarised cells, depending on the tissue where it is found []. Together with CFTR, MRP4 functions in the regulation of cAMP and beta-adrenergic contraction in cardiac myocytes []. MRP4 has been implicated in the high proliferative growth of some tumours including prostate tumours and neuroblastoma [ , ]. It confers resistance to anticancer agents including thiopurine analogues, MTX and topotecan []. This protein has a typical ABC transporter structure and each composed of two transmembrane domains (TMD1 and TMD2) and two nucleotide domains (NBD1 and NBD2).This entry represents the six-transmembrane helical domain 1 (TMD1) of ABCC4. |
| Short Name | ABCC4_TMD1 |
