Protein Domain : Rad9, Rad1, Hus1-interacting nuclear orphan protein 1 IPR029293

Type  Family
Description  This entry represents Rad9, Rad1, Hus1-interacting nuclear orphan protein 1 (RHINO or RHNO1), which plays a role in DNA damage response (DDR) signalling upon genotoxic stresses such as ionizing radiation (IR) during the S phase [ ]. RHNO1 is recruited to sites of DNA damage through interaction with the Rad9-Rad1-Hus1 (9-1-1) complex and ATR activator TopBP1. It plays a role in ATR-mediated activation of Chk1 driven by TopBP1 and 9-1-1 []. It is involved in mammary carcinogenesis [].
Short Name  RHNO1

0 Child Features

0 Gene Families

0 Genes

3 Ontology Annotations

0 Parent Features

0 Publications

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