Protein Domain : Lsr2, dimerization domain IPR042261

Type	Homologous_superfamily
Description	This superfamily represents the N-terminal dimerization domain of the Lsr2 protein, a bacterial nucleoid-associated protein involved in chromosome organization and global gene regulation. This protein binds AT-rich regions of the genome, including genomic islands acquired by horizontal gene transfer and regions encoding major virulence factors, such as the ESX secretion systems, the lipid virulence factors PDIM and PGL, and the PE/PPE families of antigenic proteins. Lsr2 has an N-terminal dimerization domain and a C-terminal DNA-binding domain. Besides enabling dimerization of Lsr2 monomers, structural studies on the N-terminal domain have shown that Lsr2 dimers show a self-associative propensity allowing chromosome compaction and gene regulation in response to external stress [ , ].
Short Name	Lsr2_dimerization