Protein Domain : Secreted effector protein SifA, C-terminal domain superfamily IPR044928

Type	Homologous_superfamily
Description	Salmonella typhimurium SifA is an effector protein that alters host cell physiology and promotes bacterial survival in host tissues. This protein is a member of the WxxxE family of bacterial TTSS effectors that mimic activated small GTPases and it is required for endosomal tubulation and formation of Salmonella-induced filaments (Sifs), which are filamentous structures containing lysosomal membrane glycoproteins within epithelial cells. Sif formation is concomitant with intracellular bacterial replication [ , ].This superfamily represents the C-terminal WxxxE-containing domain which is organised in two three-helix bundles that form a V-shaped structure. The WxxxE conserved sequence important for both the folding and the secretion of the SifA effector [ , ]. This domain also includes a six-residue prenylation motif which influences the membrane association and targeting properties of SifA [].
Short Name	SifA_C_sf

Your name:
Your email address:
Subject:
Message:	---- Current page: ---- /cicermine/report.do?id=37020185&trail=%7C37020185

CicerMine