Protein Domain : Insulin receptor substrate IPR039011

Type	Family
Description	The insulin receptor substrate protein (IRS) family consists of IRS-1, -2, -3 and -4. IRS family proteins are adapter proteins that relay signals from receptor tyrosine kinases to downstream components of signalling pathways [ ]. They are important regulatory factors in insulin signaling pathways []. When tyrosine is phosphorylated by the activated insulin receptor, the IRS proteins recruit and activate various adapter molecules or enzymes, such as phosphoinositide 3-kinase(PI3K) and mitogen-activated protein kinase (MAPK) to facilitate glucose uptake [], lipid metabolism [, ] and cell proliferation [, ].IRS proteins consist of two highly conserved domains in the N-terminal region, a pleckstrin homology (PH) domain and a phosphotyrosine-binding (PTB) domain, followed by a long, non-conserved C-terminal domain.
Short Name	IRS