Protein Domain : Putative peptidase domain, HRXXH IPR029482

Type  Domain
Description  Proteins containing this domain are putative peptidases closely related to the M35 family ( ). In this family the metal binding HEXXH motif is replaced with HRXXH. The exact function of these fungal proteins is unknown. Proteins containing this domain include members of the Zps1 (Zinc- and pH-regulated Surface protein) family [ ]. Some of them are fungal allergens; including Asp f2, a major allergen from Aspergillus fumigatus, which reacts with serum from patients with ABPA (allergic bronchopulmonary aspergillosis) [], and pH-regulated antigen 1 (PRA1) from Candida albicans, which has a role in fungal morphogenesis and perhaps in the host-parasite interaction during candidal infection [].
Short Name  HRXXH

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