Protein Domain : Sterile alpha and TIR motif-containing protein 1 IPR039184

Type  Family
Description  SARM1 (sterile alpha and TIR motif-containing protein 1) is a TIR (Toll-interleukin 1 receptor) adaptor that downregulates Toll-like receptor signalling [ , , ]. It plays a role in innate immunity []. It is also an essential mediator of axon degeneration know as Wallerian degeneration [, ]. A specific motif in its TIR domain is responsible for NAD+ loss and injury-induced SARM1 activation [, ].
Short Name  SARM1

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4 Ontology Annotations

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