Protein Domain : Max dimerization protein 1, basic Helix-Loop-Helix-zipper domain IPR040157

Type  Domain
Description  MXD1, also known as MAD, binds Max to form a repressive transcription factor. It antagonizes MYC transcriptional activity by competing for MAX [ ]. It has also been shown to regulate rRNA synthesis [].This entry represents the basic Helix-Loop-Helix-zipper (bHLHzip) domain of MXD1. The N-terminal basic region of this domain mediates high-affinity DNA-binding to specific hexanucleotide sequences [ ].
Short Name  MXD1_bHLHzip

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1 Ontology Annotations

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