LIS - Legume Information System
Information about legume traits for crop improvement
CicerMine
v5.1.0.3
Cicer data from the Legume Information System
v5.1.0.3
Cicer data from the Legume Information System
| Type | Domain |
| Description | Proteins containing this domain include one Schizosaccharomyces pombe protein Dma1 (SpDma1p), two Saccharomyces cerevisiae proteins, Dma1 (ScDma1p) and Dma2 (ScDma2p), and their homologues from fungi [ ]. They are related to the mammalian CHFR/RNF8 family of ubiquitin ligases. SpDma1p functions to prevent mitotic exit and cytokinesis during spindle checkpoint arrest by inhibiting septation initiation network (SIN) signalling []. ScDma1p and ScDma2p, also known as checkpoint forkhead associated with RING domains-containing protein 1 and 2 respectively, seem to be functionally redundant. They are involved in proper septin ring positioning and cytokinesis []. Dma1 and Dma2 are ubiquitin ligases that regulate protein kinase Swe1 levels and localization, and hence play a role in cell cycle control [ ]. The simultaneous lack of Dma1 and Dma2 leads to spindle mispositioning and defects in the spindle position checkpoint []. All members in this family contain a forkhead-associated domain (FHA) and a C3H2C3-type RING-H2 finger, the latter suggesting they may possibly possess E3 ubiquitin-ligase activities. |
| Short Name | Dma1/Dma2_RING-H2 |
