Protein Domain : Four and a half LIM domains protein 1 IPR042997

Type  Family
Description  Four and a half LIM domains protein 1 (FHL1) play an essential role in skeletal muscle growth and differentiation, acts as a scaffolding protein in sarcomere assembly and is a regulator of skeletal muscle mass and energy metabolism [ ]. It has been shown to bind to Myosin-binding protein C, regulating myosin filament formation and sarcomere assembly [ ]. Mutations of the FHL1 gene cause skeletal and heart muscle myopathy [, ]. It contains an N-terminal zinc finger/half LIM domain, followed by 4 complete LIM domains.
Short Name  Fhl1

0 Child Features

0 Gene Families

0 Genes

1 Ontology Annotations

0 Parent Features

0 Publications

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