Protein Domain : Catenin binding domain superfamily IPR027397

Type	Homologous_superfamily
Description	This superfamily represents the catenin binding domain. Proteins containing this domain include cadherins, desmocollins, desmoglein and transcription factor 7-like proteins [ , , , ].Cadherins and catenins play important roles in the adherents junctions in animal cells. The cadherin-catenin complex is responsible for coupling Ca(2+)-dependent intercellular junctions with actin dynamics and signalling pathways. Desmosomal cadherins are TM protein components of desmosomes (for review, see [ , , ]), whose extracellular cadherin repeats are responsible for adhesion and whose intracellular regions interact with intermediate filaments via desmosomal plaque proteins plakoglobin, plakobilin and desmoplakin. They are believed to play a wider role in regulation of epithelial differentiation []. Two sub-families of desmosomal cadherin have been identified, desmocollin (DSC) and desmoglein (DSG).
Short Name	Catenin-bd_sf