Protein Domain : NLRC4, helical domain IPR040535

Type  Domain
Description  This is a helical domain found in NLRC4, an nucleotide-binding and oligomerization domain-like receptor (NLR) protein. Structural and functional studies indicate that the helical domain HD2 repressively contacted a conserved and functionally important α-helix of the NBD (nucleotide binding domain) in NLRC4. Furthermore, the HD2 domain was shown to cap the N-terminal side of the LRR (leucine-rich repeat) domain via extensive interactions [ ]. Other proteins carrying this domain include baculoviral IAP repeat-containing protein 1 (Birc1), also known as neuronal apoptosis inhibitory protein (Naip).
Short Name  NLRC4_HD

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