Protein Domain : TRIM34, PRY/SPRY domain IPR035826

Type	Domain
Description	This domain, consisting of the distinct N-terminal PRY subdomain followed by the SPRY subdomain, is found at the C terminus of E3 ubiquitin-protein ligase TRIM34, also known as RING finger protein 21 (RNF21) or interferon-responsive finger protein (IFP1). TRIM proteins are defined by the presence of the tripartite motif RING/B-box/coiled-coil region and also known as RBCC proteins [ ]. The TRIM34 cDNA possesses at least three kinds of isoforms, due to alternative splicing, of which only the long and medium forms contain the SPRY domain []. It is an interferon-induced protein, predominantly expressed in the testis, kidney, and ovary []. TRIM34 functions as an antiviral protein and contributes to the defense against retroviral infections [, ]. The SPRY domain provides the capsid recognition motif that dictates specificity to retroviral restriction. While the PRY-SPRY domain provides specificity and the capsid recognition motif to retroviral restriction, TRIM34 binds HIV-1 capsid but does not restrict HIV-1 infection [].
Short Name	TRIM34_PRY/SPRY