Protein Domain : ATP-dependent Clp protease ATP-binding subunit ClpA IPR013461

Type	Family
Description	Proteins in this entry are related to ClpA ( ) from Escherichia coli. ClpA is an ATP-dependent chaperone and part of the ClpAP protease that participates in regulatory protein degradation and the dissolution and degradation of protein aggregates [ ]. ClpA functions as the regulatory component of the ATP dependent protease complex ClpAP []. ClpA recognises sequences in specific proteins, which it then unfolds in an ATP-dependent manner and transports into the degradation chamber of the associated ClpP protease [, ]. A small adaptor-like protein, ClpS, modulates the activity of ClpA and is an important regulatory factor for this protein []. It protects ClpA from autodegradation and appears to redirect its activity away from soluble proteins and toward aggregated proteins.
Short Name	ClpA