Protein Domain : Tle cognate immunity protein 4, N-terminal domain IPR040761

Type	Domain
Description	T6SS bacteria employ toxic effectors to inhibit rival cells and concurrently use effector cognate immunity proteins to protect their sibling cells. The effector and immunity pairs (E-I pairs) endow the bacteria with a great advantage in niche competition. This is the C-terminal domain of Tli4 (PA1509 in Pseudomonas aeruginosa). The Tle cognate immunity proteins (Tlis) can directly disable the transported Tle protein and thereby mediate the self-protection process. The Tle-Tli effector-immunity (E-I) pairs confer substantial advantage to the donor cell during interbacterial competition. Tli4 displays a two-domain conformation (domains I and II) and contains 17 β-strands and four helices. These two domains pack into a crab claw-like conformation functioning as an inhibitor of Tle4. Both domains adopt an alpha+beta architecture. Domain I features a central antiparallel β-sheet sandwiched by two helices and a short antiparallel β-sheet. This entry comprises the N-terminal domain I found in Tli4 proteins [ ].
Short Name	Tli4_N