Protein Domain : LIS1, N-terminal IPR037190

Type	Homologous_superfamily
Description	This entry represents the N-terminal domain of Lissencephaly-1 (LIS1). LIS1 is required for nuclear migration in fungi, cell cycle progression in mammals, and the formation of a folded cerebral cortex in humans. They appear to regulate the mechanical behaviour of cytoplasmic dynein, the primary minus-end-directed microtubule motor [ ]. Proteins containing this domain include:Platelet-activating factor acetylhydrolase IB subunit alpha, also known as Lissencephaly-1 protein [ ].Nuclear distribution protein PAC1 from budding yeasts [ ]. Fungal nuclear distribution protein nudF [ , ].Mutations in the LIS1 gene cause Lissencephaly-1, a classical lissencephaly characterised by agyria or pachygyria and disorganization of the clear neuronal lamination of normal six-layered cortex [ ].
Short Name	LIS1_N