Protein Domain : MPP6, SH3 domain IPR035603

Type	Domain
Description	This entry represents the SH3 domain of MPP6 (also known as VAM-1), which is a scaffolding protein that binds to Veli-1, a homologue of Caenorhabditis Lin-7 [ ]. MPP6 belongs to the membrane-associated guanylate kinase (MAGUK) p55 subfamily.The membrane-associated guanylate kinase (MAGUK) p55 subfamily (also known as MPP subfamily) members include the Drosophila Stardust protein and its vertebrate homologues, MPP1-7. They contain the core of three domains characteristic of MAGUK (membrane-associated guanylate kinase) proteins: PDZ, SH3, and guanylate kinase (GuK). In addition, they also contain the Hook (Protein 4.1 Binding) motif in between the SH3 and GuK domains [ ]. MPP2-7 have two additional L27 domains at their N terminus. The GuK domain in MAGUK proteins is enzymatically inactive; instead, the domain mediates protein-protein interactions and associates intramolecularly with the SH3 domain [].
Short Name	MPP6_SH3