Protein Domain : Fungal actin-binding protein 1, second SH3 domain IPR035718

Type	Domain
Description	Abp1 is an adaptor protein that functions in receptor-mediated endocytosis and vesicle trafficking [ , ]. It contains an N-terminal actin-binding module, the actin-depolymerizing factor (ADF) homology domain, a central proline-rich region, and a C-terminal SH3 domain (many yeast Abp1 proteins, such as that from Schizosaccharomyces pombe, contain two C-terminal SH3 domains). Yeast Abp1 also contains two acidic domains that bind directly to the Arp2/3 complex, which is required to initiate actin polymerization []. The SH3 domain of yeast Abp1 binds and localizes the kinases, Ark1p and Prk1p, which facilitate actin patch disassembly following vesicle internalization []. It also mediates the localization to the actin patch of the synaptojanin-like protein, Sjl2p, which plays a key role in endocytosis [].This entry represents the second SH3 domain of Abp1 from fungi such as Schizosaccharomyces pombe.
Short Name	Abp1_fungi_SH3_C2