Protein Domain : SAM and SH3 domain-containing protein 1, SH3 domain IPR035720

Type	Domain
Description	SASH1 is a potential tumour suppressor in breast and colon cancer. Its decreased expression is associated with aggressive tumour growth, metastasis, and poor prognosis [ , ]. It is widely expressed in normal tissues (except lymphocytes and dendritic cells) and is localized in the nucleus and the cytoplasm []. SASH1 interacts with the oncoprotein cortactin and is important in cell migration and adhesion. It is a member of the SLY family of proteins, which are adaptor proteins containing a central conserved region with a bipartite nuclear localization signal (NLS) as well as SAM (sterile alpha motif) and SH3 domains [].This entry represents the SH3 domain of SASH1.
Short Name	SASH1_SH3