Protein Domain : Abl Interactor 1, SH3 domain IPR035725

Type	Domain
Description	Abi1, also called e3B1, is a central regulator of actin cytoskeletal reorganization through interactions with many protein complexes. It is part of WAVE, a nucleation-promoting factor complex, that links Rac 1 activation to actin polymerization causing lamellipodia protrusion at the plasma membrane [ , ]. Abi1 is a target of alpha4 integrin, regulating membrane protrusions at sites of integrin engagement []. Abi proteins are adaptor proteins serving as binding partners and substrates of Abl tyrosine kinases. They are involved in regulating actin cytoskeletal reorganization and play important roles in membrane-ruffling, endocytosis, cell motility, and cell migration []. Abi proteins contain a homeobox homology domain, a proline-rich region, and a SH3 domain.This entry represents the SH3 domain of Abi1.
Short Name	Abi1_SH3