Protein Domain : Sorting nexin-13, PX domain IPR037437

Type	Domain
Description	SNX13, also called RGS-PX1 or sorting nexin-13, contains an N-terminal PXA domain, a regulator of G protein signaling (RGS) domain, a PX domain, and a C-terminal PXC domain [ ]. It specifically binds to the stimulatory subunit of the heterotrimeric G protein G(alpha)s, serving as its GTPase activating protein, through the RGS domain []. It is involved in development and regulation of endocytosis dynamics []. It influences the lysosomal targeting of the epidermal growth factor receptor, suggesting a role both in cell signaling and receptor trafficking [].This entry represents the PX domain of SNX13. The PX domain is a phosphoinositide (PI) binding module present in many proteins with diverse functions [ , ].
Short Name	SNX13_PX