Protein Domain : RING1 and YY1-binding protein/YY1-associated factor 2 IPR039958

Type  Family
Description  Proteins included in this entry have an N-terminal RanBP2-type zinc finger and a Yaf2/RYBP C-terminal binding motif. Proteins with these regions include Yaf2 and RYBP proteins, which are homologous parts of the PRC1 complex [ ].RYBP is a zinc finger protein with an essential role during embryonic development, which binds transcriptional factors, Polycomb products, and mediators of apoptosisis [ ]. RYBP also binds ubiquitin and Cbx proteins via the C-terminal docking module [, ]. RYBP is natively unstructured until it binds to the C-terminal region of the Polycomb protein Ring1B or to DNA []. Yaf2 binds to MYC and inhibits MYC-mediated transactivation [].
Short Name  RYBP/YAF2
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