LIS - Legume Information System
Information about legume traits for crop improvement
CicerMine
v5.1.0.3
Cicer data from the Legume Information System
v5.1.0.3
Cicer data from the Legume Information System
| Type | Domain |
| Description | This entry represents the N-terminal of the variant surface glycoproteins from Trypanosome. Proteins containing this domain include a variety of surface proteins such as variant surface glycoprotein and protein PAG1. The trypanosome parasite expresses these proteins to evade the immune response [ ]. The variant surface glycoprotein (VSG) of Trypanosoma brucei forms a coat on the surface of the parasite; by the expression of a series of antigenically distinct VSGs in the surface coat the parasite escapes the host immune response. The 2.9A resolution crystal structure of the N-terminal domain of one variant, MITat 1.2, has been determined [ ]. The "top"of the protein, which in the surface coat may be exposed to the external environment, is formed from the ends of the two long helices, a short three-stranded β-sheet, and a strand having irregular conformation that packs above these secondary structure elements. Two conserved disulphide bridges are in this part of the molecule. Several elements of the MITat 1.2 sequence, which contribute to the formation of the helix bundle structure, have been identified. These elements can be found in the sequences of several different VSGs, suggesting that to some extent the VSG structure is conserved in those variants [ , ]. |
| Short Name | Trypano_VSG_A_N_dom |
