Protein Domain : Knr4/Smi1-like domain superfamily IPR037883

Type	Homologous_superfamily
Description	This domain superfamily is found in the yeast cell wall assembly regulator Smi1 (also known as Knr4) [ , ]. Saccharomyces cerevisiae Knr4 has a regulatory role in chitin deposition and in cell wall assembly [ ]. It is believed to connect the PKC1-SLT2 MAPK pathway with cell proliferation. It has been shown to interact with Bck2, a gene involved in cell cycle progression in S. cerevisiae (forming a complex) to allow PKC1 to coordinate the cell cycle (cell proliferation) with cell wall integrity [, ]. Knr4 also interacts with the tyrosine-tRNA synthetase protein encoded by Tys1 and is involved in sporulation process []. Proteins containing this domain also include the animal F-box only protein 3 (FBXO3). In humans, FBXO3 is a substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex [ ].Interestingly, Smi1/Knr4 homologues from bacteria are potential immunity proteins in a subset of these contact-dependent inhibitory toxin systems [ , ].Note: previously reported evidence that Knr4 may interact with nuclear matrix-association region [ ] may be due to an artefact [].This domain superfamily is also found in the Syd protein which interacts with the SecY protein.
Short Name	Knr4/Smi1-like_sf