Protein Domain : Salmonella invasion protein A, C-terminal actin-binding domain superfamily IPR023224

Type  Homologous_superfamily
Description  Salmonella invasion protein A (SipA) is a virulence factor that is translocated into host cells by a type III secretion system. In the host cell it binds to actin, stimulates actin polymerisation and counteracts F-actin destabilising proteins. This contributes towards cytoskeletal rearrangements that allow the entry of the pathogen into the host cell [ ]. The actin-binding domain forms a heart-shaped helical structure that appears to be unrelated to that of other actin-binding domains [ ]. Disordered regions are present on both sides of the structural domain, forming nonglobular arms. SipA polymerises actin by stapling filaments with these nonglobular arms.
Short Name  SipA_actin-bd_C_sf
Paste the following link
Lists
This ProteinDomain isn't in any lists. Upload a list.

0 Child Features

0 Gene Families

0 Genes

0 Ontology Annotations

0 Parent Features

0 Publications

USDA
InterMine logo
The Legume Information System (LIS) is a research project of the USDA-ARS:Corn Insects and Crop Genetics Research in Ames, IA.
LegumeMine || ArachisMine | CicerMine | GlycineMine | LensMine | LupinusMine | PhaseolusMine | VignaMine | MedicagoMine
InterMine © 2002 - 2022 Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, United Kingdom