LIS - Legume Information System
Information about legume traits for crop improvement
CicerMine
v5.1.0.3
Cicer data from the Legume Information System
v5.1.0.3
Cicer data from the Legume Information System
| Type | Domain |
| Description | This entry represents the first LIM domain of ISL-1/2, which show two tandem N-terminal LIM domains and a C-terminal DNA binding homeodomain ( ). This group of proteins includes the DNA-binding transcriptional activators insulin gene enhancer proteins ISL-1/2 (also known as Islet-1/2) and its homologues from animals [, ]. ISL1 recognises and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes [, , ]. The early expression of ISL-1 in the developing hypothalamus determines the fate specification of melanocortinergic neurons and is essential for hypothalamic Pomc expression. It is required for melanocortin-induced satiety and normal adiposity throughout the entire lifespan []. ISL2 is a transcriptional factor that may define subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. |
| Short Name | ISL1/2-like_LIM1 |
