Protein Domain : Protein-arginine deiminase (PAD), N-terminal IPR013732

Type	Domain
Description	Protein arginine deiminases (PADs) use a nucleophilic cysteine to hydrolyze guanidinium groups on arginine residues to form citrulline. This reaction, known as citrullination or deimination, results in the loss of positive charge, thereby affecting protein function and altering protein-protein and protein-nucleic acid interactions. Humans encode five PADs, designated PADs 1-4 and PAD6, which regulate numerous cellular processes. PADs are dysregulated in inflammatory diseases and cancer [].The PAD2 monomer consists of two immunoglobulin-like domains, IgG1 (residues 1-115) and IgG2 (residues 116-295), as well as a C-terminal catalytic domain (residues 296-665) [ ].This entry represents the first immunoglobulin-like non-catalytic domain of protein-arginine deiminase.
Short Name	PAD_N