Protein Domain : TRC8-like, N-terminal domain IPR025754

Type  Domain
Description  This region is found at the N terminus of the TRC8 protein ( ). TRC8 is an E3 ubiquitin-protein ligase also known as RNF139. This region contains 12 transmembrane domains and has been suggested to contain a sterol sensing domain [ ]. It has been found that TRC8 protein levels are sterol responsive and that it binds and stimulates ubiquitylation of the endoplasmic reticulum anchor protein INSIG [].
Short Name  TRC8_N_dom

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