Protein Domain : Ankyrin repeat and zinc finger domain-containing protein 1/VMS1 IPR047139

Type  Family
Description  This entry represents a group of proteins predominantly found in eukaryotes, including Ankyrin repeat and zinc finger domain-containing protein 1 from human (ANKZF1) and VMS1 from Saccharomyces cerevisiae which belong to the VLRF1 (Vms1-Like Release Factor-1) clade [ ]. They have been identified as peptidyl-tRNA hydrolases that release nascent chains from stalled ribosomes []. ANKZF1, VMS1 orthologue in human, plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress []. VMS1 is a component of an evolutionarily conserved system for ubiquitin-mediated mitochondria-associated protein degradation (MAD), which is necessary to maintain mitochondrial, cellular, and organismal viability. It is involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway [, ].
Short Name  ANKZ1/VMS1
Paste the following link
Lists
This ProteinDomain isn't in any lists. Upload a list.

0 Child Features

0 Gene Families

0 Genes

0 Ontology Annotations

0 Parent Features

0 Publications

USDA
InterMine logo
The Legume Information System (LIS) is a research project of the USDA-ARS:Corn Insects and Crop Genetics Research in Ames, IA.
LegumeMine || ArachisMine | CicerMine | GlycineMine | LensMine | LupinusMine | PhaseolusMine | VignaMine | MedicagoMine
InterMine © 2002 - 2022 Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, United Kingdom