Protein Domain : KN motif and ankyrin repeat domain-containing protein 1-4 IPR047184

Type  Family
Description  This entry represents KN motif and ankyrin repeat domain-containing protein 1 (KANK1-4) from humans and similar animal proteins. KANK1 is involved in the control of cytoskeleton formation by regulating actin polymerization. It inhibits actin fibre formation, cell migration and fibronectin-mediated cell spreading. This protein is involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. [ , ]. KANK2 is involved in regulation of caspase-independent apoptosis, in the negative control of vitamin D receptor signalling pathway and in actin stress fibres formation [, , , ]. These proteins have been associated with nephrotic syndrome [].
Short Name  KANK1-4
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