Protein Domain : Arterivirus NSP4 peptidase domain IPR023338

Type	Domain
Description	Arteriviruses are enveloped, positive-stranded RNA viruses and include pathogens of major economic concern to the swine- and horse-breedingindustries:Equine arteritis virus (EAV).Porcine reproductive and respiratory syndrome virus (PRRSV).Mice actate dehydrogenase-elevating virus.Simian hemorrhagic fever virus.The arterivirus replicase gene encodes two large precursor polyproteins thatare processed by the viral main proteinase nonstructural protein 4 (NSP4). The structure of the enzyme reveals two chymotrypsin-like antiparallel beta-barrels and an extra C-terminal alpha/beta domain that may play a role in mediating protein-protein interactions. The N-terminalbarrel consists of six β-strands (A1 to F1), while the C-terminal barrel is composed of seven (A2 to G2). The core of both β-barrels is comprised ofconserved hydrophobic residues. The additional C-terminal domain consists of two pairs of short antiparallel β-sheets and two α-helices. Itinteracts with the C-terminal barrel through an interface consisting of conserved hydrophobic residues. A canonical catalytic triad that is composedof Ser, His, and Asp is located in the open cleft between the β-barrels domain [, ]. The nsp4 proteinase domain is a member of peptidase family S32.The is entry represents the NSP4 proteinase domain.
Short Name	Arterivirus_NSP4_peptidase