Protein Domain : Herpes simplex virus, Tegument protein VP16, C-terminal IPR021051

Type  Domain
Description  This domain is found in the C-terminal region of the HSV virion protein 16 (VP16 or Alpha-TIF) from Herpes Simplex virus. It appears in association with and is about 30 amino acids in length. It is the carboxyl subdomain of the acidic transcriptional activation domain. VP16 is a transcription promoter, an essential activator of viral immediate early (IE) promoters (alpha genes) during the lytic phase of viral infection. The protein associates with cellular transcription factors and DNA binding proteins to to enhance transcription rates. Such proteins include TATA binding protein, CBP, TBP-binding protein, etc. The C-terminal residues of the protein are responsible for transcriptional activation. Within the C-terminal region there are two activation regions that can independently and cooperatively activate transcription [ , , ].
Short Name  HSV_VP16_C

0 Child Features

0 Gene Families

0 Genes

0 Ontology Annotations

0 Parent Features

0 Publications

USDA
InterMine logo
The Legume Information System (LIS) is a research project of the USDA-ARS:Corn Insects and Crop Genetics Research in Ames, IA.
LegumeMine || ArachisMine | CicerMine | GlycineMine | LensMine | LupinusMine | PhaseolusMine | VignaMine | MedicagoMine
InterMine © 2002 - 2022 Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, United Kingdom