Protein Domain : Receptor of activated protein kinase C 1 RACK1/Asc1 IPR045223

Type	Family
Description	This entry includes Asc1 from yeasts and RACK1 from animals. They are core 40S ribosomal proteins that repress gene expression [] and involved in induction of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation [, ]. The seven-bladed β-propeller structure of RACK1 is located near the mRNA exit tunnel where it makes contacts with the ribosomal RNA through lysine and arginine residues and neighbouring ribosomal proteins []. Asc1/RACK1 are key factors in phosphosignaling and functions as a control point at the head of the ribosomal 40S subunit itself regulated through posttranslational modification []. RACK1 also serves as a scaffold protein that can recruit other proteins to the ribosome and also for a wide range of kinases and membrane bound receptors [, ]. It has been shown to regulates axonal growth [] and is essential for development in mice, Drosophila melanogaster and Arabidopsis thaliana [, , ].
Short Name	RACK1/Asc1